What does the term stroma refer to in relation to tumors?

The term stroma is used to describe the supportive tissue surrounding tumor cells. In the context of tumors, the stroma comprises the connective tissue, blood vessels, immune cells, and other components that provide structural support and facilitate the function of the tumor. This supportive tissue plays a crucial role in the tumor microenvironment, influencing tumor growth, progression, and response to treatment.

The stroma is distinct from the cancerous cells themselves; it forms the ecosystem in which these cells exist. Understanding the role of stroma is essential in pathology because it can affect tumor behavior, metastasis, and the effectiveness of therapeutic approaches. By focusing on the stroma, researchers and clinicians can develop strategies to target not just the tumor cells but also their supportive environment, which can be pivotal in improving treatment outcomes.